Andreia Sofia Bernardo

WNT inhibition primes the transcriptional landscape of mesoderm to initiate a phased ventricular cardiomyocyte specification programme

This study identifies WNT inhibition-dependent and -independent transcriptional regulators guiding human ventricular cardiomyocyte specification using single-cell RNA sequencing.

Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

Developmental Dynamics of Human Cardiogenesis: A multi-omic reference and its disruption in Trisomy 21

This study develops a multi-omic reference of human cardiac development and identifies disruptions in Trisomy 21 hearts.

In-vitro cellular reprogramming to model gonad development and its disorders

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

Rostrocaudal Patterning and Neural Crest Differentiation of Human Pre-Neural Spinal Cord Progenitors in vitro

This study generates and characterizes human pre-neural spinal cord progenitors that can self-renew and differentiate into neural crest cells while adopting rostrocaudal identities.