Author

Patrícia R. Pitrez

Centro de Inovação em Biomedicina e BiotecnologiaORCID 0000-0002-3116-0723Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alessandro Ori‬‬iD· 1 shared Andreia Sofia BernardoiD· 1 shared Antonio MarinoiD· 1 shared Carlos Sousa-SoaresiD· 1 shared Célia Alexandra AveleiraiD· 1 shared Deolinda R. SantinhaiD· 1 shared Elsa LogarinhoiD· 1 shared James C. SmithiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Alessandro Ori‬‬ORCID

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1 paper

Recent·Most cited

Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation

Luís Miguel Monteiro, Patrícia R. Pitrez, Simão Correia-Santos, Nicola Dark, Deolinda R. Santinha, Célia Alexandra Aveleira, Megan Townsend, James Taylor, Xavier Nissan, Vilma A. Sardão, Luísa Cortes, Richard Mitter, Antonio Marino, Carlos Sousa-Soares, Rui Ribeiro, , Lino Ferreira

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

bioRxiv · Jun 27, 2025 · PreprintCell Biology