Author

Jae Ho Lee

Stanford UniversityORCID 0000-0002-8663-3209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Judith FrydmaniD· 2 shared Alessandro CellerinoiD· 1 shared Alessandro Ori‬‬iD· 1 shared Amit Kumar SahuiD· 1 shared Ann-Kathrin KöhleriD· 1 shared Antonio MarinoiD· 1 shared Domenico Di FraiaiD· 1 shared Ekaterina SamatovaiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Judith FrydmanORCID

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2 papers

Recent·Most cited

NAC controls nascent chain fate through tunnel sensing and chaperone action

Jae Ho Lee, Laurenz Rabl, Martin Gamerdinger, Vaishali Goyal, Katrin M. Khakzar, Natália M. Barbosa, Juliana Abramovich, Fabián Morales-Polanco, Ann-Kathrin Köhler, Ekaterina Samatova, Marina V. Rodnina, Elke Deuerling, Judith Frydman

This study identifies NAC's role in regulating translation elongation, cotranslational folding, and organelle targeting through sequence-specific interactions with nascent polypeptides.

Nature · Dec 22, 2025Peer-reviewedBiochemistry

Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain

Domenico Di Fraia, Antonio Marino, Jae Ho Lee, Erika Kelmer Sacramento, Mario Baumgart, Sara Bagnoli, Pedro Tomaz da Silva, Amit Kumar Sahu, Giacomo Siano, Max Tiessen, Eva Terzibasi-Tozzini, Julien Gagneur, Judith Frydman, Alessandro Cellerino, Alessandro Ori‬‬

The paper shows that aging in killifish brains reduces basic amino acid-rich proteins through translation pausing, not transcription or proteasome issues, revealing a vulnerability in nucleic-acid protein biogenesis.

bioRxiv · Jul 20, 2023 · PreprintSystems Biology