Jongcheol Jeon

Dynamics of TFIIH and Spt4/5 during the transition from transcription initiation to elongation

The paper uses single-molecule fluorescence microscopy to show that TFIIH dissociates from RNA polymerase II before Spt4/5 binds, indicating Spt4/5 does not actively displace TFIIH.

A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence

The paper uses single-molecule microscopy to show Mediator recruitment to promoters is synergistic when multiple activators bind, revealing a non-cooperative mechanism.

Single-molecule analysis of transcription activation: Dynamics of SAGA co-activator recruitment

This study uses single-molecule microscopy to analyze SAGA co-activator dynamics during transcription activation, revealing two distinct modes of interaction with DNA and activators.

The activity-dependent transcription factor Npas4 regulates IQSEC3 expression in somatostatin interneurons to mediate anxiety-like behavior

This study shows that Npas4 regulates IQSEC3 expression in SST interneurons, affecting GABAergic synapse function and anxiety-like behavior.