Jané Kondev

The paper investigates how many mutations are needed to evolve a new function using a Boolean-network model of genotype-phenotype maps, showing a power-law scaling with network size.

The paper explores exploratory dynamics in biological processes, proposing mathematical frameworks like geometric distribution and random walks with resets to model search processes and their outcomes.

The paper uses theory and simulation to show that membrane surfaces can accelerate actin filament assembly by clustering polymerases, even at high actin concentrations.

The paper shows that bacterial RNA polymerase's C-terminal domains accelerate DNA binding through a physical mechanism involving flexible tethers.

The paper uses single-molecule microscopy to show Mediator recruitment to promoters is synergistic when multiple activators bind, revealing a non-cooperative mechanism.

The paper proposes exploratory dynamics as a framework for understanding biological processes that achieve specific outcomes through repeated, random trajectories.

This study shows that transcription of ribosomal RNA actively drives nucleolar assembly in C. elegans embryos, explaining rapid kinetics and scaling with nuclear volume.

This paper shows that yeast cells control actin cable length through geometric organization rather than molecular feedback mechanisms.

The paper quantifies the relationship between bacterial growth rate, cell size, and protein content in E. coli using proteomic data, finding ribosome biogenesis as a primary determinant of growth rate.

The paper quantifies how phenotypic variability affects microbial population fitness in fixed-size populations and shows how environmental fluctuations disrupt this relationship.

The paper develops a model of flagellar length control in Chlamydomonas reinhardtii, showing that a limiting pool of IFT proteins leads to an inverse growth-rate-length relationship and identifies coupling mechanisms that enable simultaneous length control.