Tyler S. Harmon

Mechanical regulation of endocytosis by protein droplet capillary forces

This study investigates how protein droplet capillary forces regulate clathrin-mediated endocytosis by stalling and then driving membrane invagination.

Born to Condense: Polysomes Drive Co-Translational Condensation of Biomolecular Condensate Proteins

This paper introduces a theoretical framework for co-translational condensation (CTC), showing how polysomes drive the formation of biomolecular condensates through protein synthesis.

Droplet-assisted folding of long regulatory RNAs

The paper proposes a mechanism called droplet-assisted RNA folding, where RNA-binding protein condensates guide the folding of long regulatory RNAs by preventing premature interactions and enabling long-range contacts.

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.

The Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates

This study uses simulations to show coiled-coil domains promote liquid-liquid phase separation by preventing loop-closure defects and enabling protein networking.

Transport kinetics across interfaces between coexisting liquid phases

The paper derives a model for molecular transport across phase boundaries in coexisting liquid phases and identifies two physical scenarios that lead to an effective transport resistance.