Author

Lahari Das

Albert Einstein College of MedicineORCID 0000-0002-8951-9532Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

William R. JacobsiD· 2 shared Álvaro San MillániD· 1 shared Ángel Ruiz-EnamoradoiD· 1 shared Benjamin N. KoleskeiD· 1 shared Catherine VilchèzeiD· 1 shared Courtney SchilliD· 1 shared Isabel Martín-BlecuaiD· 1 shared Jesús BlázqueziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

William R. JacobsORCID

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2 papers

Recent·Most cited

The unique role of nucS-mediated non-canonical mismatch repair in Mycobacterium tuberculosis resistance evolution

Isabel Martín-Blecua, José Ramón Valverde, Pablo García-Bravo, Ángel Ruiz-Enamorado, Rafael Prados‐Rosales, Jorge Sastre-Domínguez, Lahari Das, William R. Jacobs, Álvaro San Millán, Jesús Blázquez, Sonia Gullón

This study investigates the role of NucS-mediated non-canonical mismatch repair in Mycobacterium tuberculosis and finds it does not significantly affect resistance to key antibiotics.

mBio · Dec 22, 2025Peer-reviewedMicrobiology

Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion

Benjamin N. Koleske, Rajagopalan Saranathan, Courtney Schill, Shichun Lun, Catherine Vilchèze, Lahari Das, Manish Kumar Gupta, Yazmin B. Martinez-Martinez, William R. Bishai, William R. Jacobs

This study shows that deleting the ESX-5 secretion system in Mycobacterium tuberculosis reduces ESX-5 substrate secretion, increases ESX-1 substrates, decreases ESX-3 expression, and alters cell morphology and antibiotic susceptibility.

Proceedings of the National Academy of Sciences · Sep 3, 2025Peer-reviewedMicrobiology