This study identifies functional neural signatures of navigation impairment in early Alzheimer's Disease by linking biomarkers to specific brain activity patterns during navigation tasks.

bioRxiv · Jun 29, 2026 · PreprintNeuroscience

Bivariate GSA-MiXeR: A Novel Tool for Functional Genomic Analyses Implicates Diverse Neural Cell Types for Psychiatric and Neurodegenerative Disorders

Nadine Parker, Julian Furher, Dat Thanh Nguyen, Vera Fominykh, Piotr Pawel Jaholkowski, Ibrahim A. Akkouh, Kevin Sean O’Connell, Espen Hagen, Shahram Bahrahmi, Dag Årsland, Sverre Bergh, Torgeir A Engstad, Tormod Fladby, Anne‐Brita Knapskog, Karin Persson, , Oleksandr Frei

Bivariate GSA-MiXeR is a tool that models genetic correlations between two traits to identify genomic regions associated with psychiatric and neurodegenerative disorders using single-cell RNA sequencing data.

medRxiv · Dec 17, 2025 · PreprintGenetic & Genomic Medicine

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

Douglas P. Wightman, Iris E. Jansen, Jeanne E. Savage, Alexey A. Shadrin, Shahram Bahrami, Arvid Rongve, Sigrid Børte, Bendik Slagsvold Winsvold, Ole Kristian Drange, Amy E. Martinsen, Anne Heidi Skogholt, Cristen J. Willer, Geir Bråthen, Ingunn Bosnes, Jonas Bille Nielsen, , Daniëlle Posthuma

This study identifies seven novel genetic loci for Alzheimer's disease using a large GWAS and highlights microglia and immune pathways as key contributors to disease pathology.

medRxiv · Nov 20, 2020 · PreprintGenetic & Genomic Medicine

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

Iris E. Jansen, Jeanne E. Savage, Kyoko Watanabe, Julien Bryois, Dylan M. Williams, Stacy Steinberg, Julia Sealock, Ida Karlsson, Sara Hägg, Lavinia Athanasiu, Nicola Voyle, Petroula Proitsi, Aree Witoelar, Sven Stringer, Dag Aarsland, , Daniëlle Posthuma

This study identifies 9 novel genetic loci and 215 potential causative genes associated with Alzheimer's disease risk through a large genome-wide association analysis.

bioRxiv · Feb 22, 2018 · PreprintGenetics