This study examines chronic intranasal oxytocin's effects on neuroanatomy and behavior in three autism-related mouse models, finding limited effects and no consistent response patterns.

NeuroImage · May 1, 2022Peer-reviewedDevelopmental Biology

Neuroanatomy and Behaviour in Mice with a Haploinsufficiency of AT-Rich Interactive Domain 1B (ARID1B) Throughout Development

Jacob Ellegood, Stela P. Petkova, Adrienne I. Kinman, Lily R. Qiu, Anna Adhikari, A. Ayanna Wade, Darren Fernandes, Zsuzsa Lindenmaier, Amie Creighton, Lauryl M. J. Nutter, Alex S. Nord, Jill L. Silverman, Jason P. Lerch

This study investigates the effects of Arid1b haploinsufficiency in mice, revealing sex-dependent neuroanatomical and behavioral phenotypes associated with neurodevelopmental disorders.

Molecular Autism · Mar 23, 2021Peer-reviewedNeuroscience

Characterization of Mice Bearing Humanized Androgen Receptor Genes (h/mAr) Varying in Polymorphism Length

Zsuzsa Lindenmaier, Yohan Yee, Adrienne I. Kinman, Darren Fernandes, Jacob Ellegood, Christie L. Burton, Diane M. Robins, Armin Raznahan, Paul Daniel Arnold, Jason P. Lerch

This study characterizes the effects of varying humanized androgen receptor Q tract lengths on brain anatomy and behavior in mice, finding non-linear neuroanatomical changes and no behavioral effects.

NeuroImage · Nov 25, 2020Peer-reviewedNeuroscience