Marco Rasponi

An Innervated and Vascularized HNSCC-on-a-Chip Model Built on Defined and Tunable Engineered Extracellular Matrices

This paper develops an HNSCC-on-a-chip model with tunable engineered extracellular matrices, vasculature, and innervation to study tumor behavior and therapeutic responses.

Cardiac fibroblast cellular anisotropy is determined by YAP-dependent cellular contractility and ECM production

This study shows YAP in cardiac fibroblasts controls ECM structure and fibroblast alignment, affecting cardiomyocyte function and tissue integrity.

Von Willebrand Factor Deficiency Impairs Vascular Morphogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia

This study shows that VWF deficiency increases Angpt-2 expression via the Tie2-Akt-FOXO1 pathway, leading to vascular defects in the gut and suggesting Angpt-2 inhibitors could treat VWD-related bleeding.

An iPSC-derived bio-inspired scaffold modelling the structure and the effects of extracellular matrix in cardiac fibrosis

This paper develops a bio-inspired scaffold from iPSC-derived cardiac myofibroblasts to model fibrotic ECM effects on cardiomyocytes.