Liping Wang

Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks

This study shows that protein condensates and clathrin assembly regulate each other during clathrin-mediated endocytosis, enhancing vesicle formation while controlling condensate growth.

Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis

This study shows Epsin1 stabilizes initiator protein condensation during clathrin-mediated endocytosis only when ubiquitin is present, ensuring cargo-specific vesicle formation.

Liquid-like condensates that bind actin drive filament polymerization and bundling

The paper shows that actin-binding proteins forming liquid-like condensates can polymerize and bundle actin filaments, expanding the known set of proteins capable of this function.