Poly-ubiquitylated transmembrane proteins outcompete other cargo for limited space inside clathrin-coated vesicles
Haoyang Liu, Susovan Sarkar, Feng Yuan, Grant Ashby, Carl C. Hayden, Jon M. Huibregtse, Jeanne C. Stachowiak
This study shows poly-ubiquitylated transmembrane proteins outcompete mono-ubiquitylated and non-ubiquitylated proteins for endocytic uptake by clathrin-coated vesicles.
Cell Reports · Oct 25, 2025Peer-reviewedCell Biology