Eric Cornes

Quantitative Description of C. elegans mRNA Landscapes From High Coverage Single Cell Transcriptomes

The paper develops a method to analyze high-coverage single-cell RNA-seq data to identify gene expression patterns in C. elegans cells without dimensional reduction.

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

The paper shows that CSR-1 slicer activity and codon usage regulate 22G-RNA biogenesis in C. elegans germline mRNAs.

Germline inherited small RNAs clear untranslated maternal mRNAs in C. elegans embryos

This study shows that C. elegans embryos use inherited small RNAs to cleave and remove maternal mRNAs through the catalytic activity of Argonaute CSR-1.

Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development

This study identifies a role for C. elegans I{kappa}B homologs in chromatin regulation, showing they bind histones, Polycomb proteins, and alter chromatin marks, suggesting ancestral I{kappa}B functions in development.