Author

David Brena

Institut d'Investigació Biomédica de BellvitgeORCID 0000-0003-3318-5120Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Organism:zebrafish· 1

Frequent Co-Authors

Dmytro KukhtariD· 2 shared Julián CeróniD· 2 shared Abul Bashar Mir Md. Khademul IslamiD· 1 shared Albert García LópeziD· 1 shared Alejandro RubioiD· 1 shared Anna BigasiD· 1 shared Antonio J. GiráldeziD· 1 shared Antonio J. Pérez‐PulidoiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Dmytro KukhtarORCID

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2 papers

Recent·Most cited

GeneticsNature CommunicationsPeer-reviewedMay 12, 2022

Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes

Jeremy Vicencio, Carlos Sánchez-Bolaños, Ismael Moreno-Sánchez…·Miguel A. Moreno-Mateos

This study demonstrates the use of SpG and SpRY CRISPR-Cas9 variants in zebrafish and C. elegans for genome editing, showing improved accessibility to previously uneditable sites.

48 citationstop 5%

zebrafishC. elegans

𝕏 PostBluesky

Developmental BiologyScientific ReportsPeer-reviewedSep 30, 2020

Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development

David Brena, Joan Bertran, Montserrat Porta-de-la-Riva…·Lluı́s Espinosa

This study identifies a role for C. elegans I{kappa}B homologs in chromatin regulation, showing they bind histones, Polycomb proteins, and alter chromatin marks, suggesting ancestral I{kappa}B functions in development.

19 citations

C. elegansstatistical model

𝕏 PostBluesky