Author

Estelle Lecluze

Centre Hospitalier Universitaire Sainte-JustineORCID 0000-0002-2940-8339Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Guillaume LettreiD· 2 shared Anne-Laure Pham Hung D'Alexandry D'OrengianiiD· 1 shared Barbara NicoliD· 1 shared Blanche CapeliD· 1 shared Elodie Dupin-De-Beyssat· 1 shared Éric PailhouxiD· 1 shared F. GalactérosiD· 1 shared Frédéric ChalmeliD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Guillaume LettreORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Genetic contribution to asthma informs acute chest syndrome pathophysiology and risk stratification

Sara El Aouhel, Vanessa Bellegarde, Stennio Da Silva Faria, Tristan St-Laurent, Estelle Lecluze, Anne-Laure Pham Hung D'Alexandry D'Orengiani, F. Galactéros, Pablo Bartolucci, Marc‐André Legault, Guillaume Lettre, Thomas Pincez

This study uses polygenic scores to show asthma genetics are linked to ACS recurrence risk, but not occurrence, and highlights the role of HbF in modulating this risk.

American Journal of Hematology · Feb 27, 2026Peer-reviewedGenetic & Genomic Medicine

Association analyses of predicted loss-of-function variants prioritized 15 genes as blood pressure regulators

Estelle Lecluze, Guillaume Lettre

The paper identifies 15 genes associated with blood pressure regulation by analyzing loss-of-function variants in a large exome sequencing dataset.

Canadian Journal of Cardiology · Jul 12, 2023Peer-reviewedGenetic & Genomic Medicine

RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2

Barbara Nicol, Sara A. Grimm, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier, Éric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey Hung‐Chang Yao

The paper identifies RUNX1 as a conserved regulator of fetal ovarian supporting cell identity, showing its interaction with FOXL2 in maintaining granulosa cell fate across species.

Nature Communications · Nov 11, 2019Peer-reviewedDevelopmental Biology