Stephen Nurrish

MEF-2 repression of GEM-4/Copine expression decreases muscle excitability by increasing gap junction coupling

The paper identifies gem-4/Copine as a target of MEF-2 and CRH-1/CREB that reduces gap junction coupling and increases muscle excitability in C. elegans.

A repressive regulatory cascade shapes temporal patterning of activity-regulated gene expression in a defined sensory neuron type

TRAP-seq of C. elegans AFD neurons reveals three temperature-duration expression modules; CREB-driven RCAN-1 acts in parallel with MEF-2 to repress premature expression of a delayed gene, ins-39.

Neuron-intrinsic and glial pathways regulate sensory cilia regeneration in adult C. elegans

This study shows that sensory neuron cilia in adult C. elegans can regenerate after injury, involving both cell-intrinsic and glial pathways distinct from developmental ciliogenesis.

Immature C. elegans motor neurons control early embryo behavior via both synaptic and non-synaptic GABA release

The paper shows that immature GABAergic motor neurons in C. elegans embryos transiently inhibit motion via both synaptic and non-synaptic GABA release before synapse formation.

Experience-dependent reconfiguration of receptors at a sensory compartment regulates neuronal plasticity

The paper shows temperature experience modulates transcription and trafficking of thermoreceptors in C. elegans AFD neurons to regulate response plasticity.

A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity in C. elegans

The paper shows that asymmetric molecular mechanisms in C. elegans AWC neurons drive symmetric odor response plasticity, revealing how lateralized signaling enhances behavioral flexibility.

CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission

This study identifies CASK and FARP as scaffolding proteins that localize post-synaptic ACh receptors, enhancing cholinergic transmission in C. elegans.

Stereotyped behavioral maturation and rhythmic quiescence in C. elegans embryos

The paper describes the stereotyped behavioral maturation of C. elegans embryos, identifying a rhythmic quiescence phase driven by a specific neuron.

Shank promotes action potential repolarization by recruiting BK channels to calcium nanodomains

Caenorhabditis elegans junctophilin has tissue-specific functions and regulates neurotransmission with extended-synaptotagmin

This study investigates the tissue-specific functions of C. elegans JPH-1, showing its role in neurotransmission and muscle contraction, and its interaction with calcium channels.