BioengineeringbioRxivPreprint
High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics
DOI 10.1101/2024.03.14.585126
Author
Stanley Z. Lam
Yale UniversityORCID 0000-0002-2951-4246Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2021-2024 · peak 1/yrCo-Author Collaboration Network
10 top collaborators · 33 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship3 papers
Recent·Most cited
- GenomicsJournal of Hematology & OncologyPeer-reviewed
Double knockout CRISPR screen in cancer resistance to T cell cytotoxicity
Jonathan Joon-Young Park, Adan Codina, Lupeng Ye…·Sidi Chen
The paper identifies genetic interactions between cancer mutations and immune resistance genes using a CRISPR double knockout screen, revealing potential targets for existing drugs.
16 citations - BioinformaticsbioRxivPreprint
T cell receptor repertoire signatures associated with COVID-19 severity
Jonathan Joon-Young Park, Kyoung A. Viola Lee, Stanley Z. Lam, Sidi Chen
The paper analyzes T cell receptor repertoires from COVID-19 patients and healthy donors to identify signatures associated with disease severity and develops machine learning models to predict severity based on TCR features.