Shao‐Yu Fang

This paper introduces cTACs, synthetic molecules that degrade PD-L1 across immune and tumor cells, enhancing T cell activation and tumor suppression in vivo.

This study shows that loss of Ms4a4a remodels microglial transcriptional programs and reduces dense-core plaque-associated tau spreading in a mouse model of Alzheimer's disease.

The paper demonstrates efficient multiplexed gene editing in immune cells using Cas12a/Cpf1 knock-in mice and associated viral vectors.