Kaiyuan Tang

This paper introduces cTACs, synthetic molecules that degrade PD-L1 across immune and tumor cells, enhancing T cell activation and tumor suppression in vivo.

This paper introduces CAR-T-drug conjugates (CAR-T-D-C) to improve CAR-T therapy for solid tumors by combining chemotherapy with CAR-T cells, enhancing tumor infiltration and immune response.

The paper introduces TCPGdb, a database integrating T cell perturbation screens to identify critical regulators of T cell function and anti-tumor persistence.

The paper demonstrates efficient multiplexed gene editing in immune cells using Cas12a/Cpf1 knock-in mice and associated viral vectors.