Xiaoyu Zhou

Engineered CTLA-4 targeting chimeras for targeted protein degradation and immune synapse reprogramming

This paper introduces cTACs, synthetic molecules that degrade PD-L1 across immune and tumor cells, enhancing T cell activation and tumor suppression in vivo.

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

Cas12a/Cpf1 knock-in mice enable efficient multiplexed immune cell engineering

The paper demonstrates efficient multiplexed gene editing in immune cells using Cas12a/Cpf1 knock-in mice and associated viral vectors.

Double knockout CRISPR screen in cancer resistance to T cell cytotoxicity

The paper identifies genetic interactions between cancer mutations and immune resistance genes using a CRISPR double knockout screen, revealing potential targets for existing drugs.