Author

Alexander A. Mestre

Duke UniversityORCID 0000-0002-2963-1354Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Chao‐Chieh LiniD· 3 shared Jen‐Tsan ChiiD· 3 shared Ssu-Yu CheniD· 3 shared Yasaman SetayeshpouriD· 3 shared Chiara Federico· 2 shared Jianli WuiD· 2 shared Andrew BerchuckiD· 1 shared C. Skyler CochraneiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

Chao‐Chieh LinORCID

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3 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedMay 11, 2026

Ascitic fluid protects against ferroptosis and enables the peritoneal spread of ovarian cancer

Yasaman Setayeshpour, S Chen, Divya Lakshmi Dayanidhi…·Jen‐Tsan Chi

This study shows ascites protects ovarian cancer cells from ferroptosis and promotes peritoneal metastasis by modulating lipid metabolism and iron homeostasis.

5 citationstop 1%

mousehuman

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BiochemistrybioRxivPreprintFeb 20, 2026

Identification of 4,5,6,7-Tetrabromo-1H-benzotriazole (TBB) as a Small Molecule MESH1 Inhibitor that Suppresses Ferroptosis

Alexander A. Mestre, Yunju Oh, Jianli Wu…·Jen‐Tsan Chi

This paper identifies TBB as a small molecule inhibitor of MESH1 that suppresses ferroptosis in vitro and reduces neuronal death in an Alzheimer's disease model.

DOI 10.64898/2026.02.19.706832

humanproteomics

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Cancer BiologyCell Death and DiseasePeer-reviewedOct 18, 2024

NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation

Ssu-Yu Chen, Jianli Wu, Yubin Chen…·Jen‐Tsan Chi

This paper shows NINJ1 protects cancer cells from ferroptosis by interacting with xCT antiporter and modulating CoA and GSH levels.

33 citationstop 4%

humanproteomics

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