Author

Yuning Zhang

Duke UniversityORCID 0000-0002-2967-4207Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yuning Zhang2 papers · BGI Group (China)

Biology Disciplines

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Genomics· 2 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Raluca GordâniD· 4 shared John Horton· 2 shared Alan S Brown· 1 shared Alex George· 1 shared B. Z. HeiD· 1 shared Baylee J Bruce· 1 shared Caitlin V. JohnsoniD· 1 shared Dan LeehriD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersGenomics

Raluca GordânORCID

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4 papers

Recent·Most cited

UV irradiation alters TFAM binding specificity and compaction of DNA

Dillon E. King, Emily E. Beard, Matthew Satusky, Alex George, Ian T. Ryde, Caitlin V. Johnson, Emma L. Dolan, Yuning Zhang, Wei Zhu, Hunter Wilkins, Evan Corden, Susan K. Murphy, Dorothy A. Erie, Raluca Gordân, Joel N. Meyer

This study shows that UVC irradiation changes TFAM's DNA binding specificity and increases mtDNA compaction, but does not protect against DNA damage.

eLife · Mar 25, 2026Peer-reviewedBiochemistry

Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions

Lindsey F. Snyder, Emily M O'Brien, Jia Zhao, Jinye Liang, Baylee J Bruce, Yuning Zhang, Wei Zhu, Thomas Cassier, Nicholas Schnicker, Xu Zhou, Raluca Gordân, B. Z. He

The paper examines how divergence in intrinsically disordered regions of a eukaryotic transcription factor affects its co-TF dependence across species.

Nature Communications · Jun 18, 2025Peer-reviewedEvolutionary Biology

DNA sequence context and the chromatin landscape differentiate sequence-specific transcription factor binding in the human malaria parasite, Plasmodium falciparum

Victoria Ann Bonnell, Yuning Zhang, Alan S Brown, John Horton, Gabrielle A. Josling, Tsu-Pei Chiu, Remo Rohs, Shaun Mahony, Raluca Gordân, Manuel Llinás

The paper investigates how DNA sequence and chromatin context influence transcription factor binding in Plasmodium falciparum, showing that both factors contribute to differential binding site selection.

Nucleic Acids Research · Jun 27, 2024Peer-reviewedGenomics

Intrinsic specificity differences between transcription factor paralogs partly explain their differential in vivo binding

Ning Shen, Jingkang Zhao, J.L. Schipper, Yuning Zhang, Tristan Bepler, Dan Leehr, John Bradley, John Horton, Hilmar Lapp, Raluca Gordân

The paper identifies intrinsic DNA-binding specificity differences between transcription factor paralogs that partly explain their distinct genomic binding patterns.

Cell Systems · Mar 28, 2018Peer-reviewedGenomics