Sarah E. Dremel

This study shows that Brf1-mediated RNA polymerase III activity restricts murine gammaherpesvirus spread by enhancing host antiviral responses during low MOI infections.

This study shows that interferon-induced H3K9me3 and ATRX restrict HSV-1 reactivation by maintaining epigenetic memory during neuronal latency.

This study investigates how HSV-1 manipulates RNA Polymerase III by increasing tRNA expression and altering transcriptional machinery interactions.

This study identifies HSV-1 ICP4 as a key factor in recruiting host transcription machinery to the viral genome, leading to host transcriptional shut off.