Author

Sixue Zhang

University of Alabama at BirminghamORCID 0000-0002-2981-9154Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Fuad Al AbiriD· 2 shared Jake Y. CheniD· 2 shared Alec J. HirschiD· 1 shared Chander RamaniD· 1 shared Corinne E. Augelli‐SzafraniD· 1 shared Craig Elmets· 1 shared David K. CrossmaniD· 1 shared Delower HossainiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioengineering

Fuad Al AbirORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A broadly active flavivirus NS4B targeting compound that blocks NS4B-NS3 binding and replication organelle formation

Jessica Louise Smith, Theresa Hoang-Anh Nguyen, Sixue Zhang, Omar Moukha‐Chafiq, Corinne E. Augelli‐Szafran, Alec J. Hirsch

This paper identifies SRI-38841, a xanthine analog that inhibits multiple flaviviruses by blocking NS4B-NS3 interaction and replication organelle formation.

bioRxiv · Oct 30, 2026 · PreprintMicrobiology

Human skin fibrosis with iPSC-derived organoids reveals RUNX2-mediated fibroblast reprogramming

Jasim Khan, Sarmad Mehmood, Fuad Al Abir, Miao Wei, Suhail Muzaffar, Suha Mohiuddin, Shanrun Liu, Mohammad Waseem, Juheb Akhter, Zhipeng Liu, David K. Crossman, Masakazu Kamata, Jake Y. Chen, Chander Raman, Craig Elmets, , Lin Jin

This study uses human iPSC-derived skin organoids to model fibrosis, identifies RUNX2 as a key driver, and finds a small molecule that suppresses fibrotic programs.

bioRxiv · Sep 16, 2026 · PreprintBioengineering

Benchmarking Generative Large Language Models for de novo Antibody Design and Agentic Evaluation

Delower Hossain, Fuad Al Abir, Sixue Zhang, Jake Y. Chen

This study benchmarks compact transformer models for de novo antibody design, finding no significant architectural differences in performance at small scales.

bioRxiv · Apr 21, 2026 · PreprintBioinformatics