Suresh Sudarsan

Interaction of Genetic Variants Activates Latent Metabolic Pathways in Yeast

The paper investigates how genetic variant interactions in yeast activate latent metabolic pathways and modulate phenotypic outcomes during sporulation.

Deciphering the transcriptional regulatory network of Yarrowia lipolytica using machine learning

This paper uses machine learning to analyze transcriptomic data from Yarrowia lipolytica under various industrial stresses, identifying regulatory modules and their responses to environmental changes.

The dominant role of post-transcriptional regulation in Yarrowia lipolytica to repeated O2 limitations

This study investigates Yarrowia lipolytica's response to repeated oxygen limitations using a multi-omics approach, revealing that post-transcriptional regulation dominates its adaptation to industrial conditions.

Regulatory control circuits for stabilizing long-term anabolic product formation in yeast

The paper designs synthetic control circuits in yeast to stabilize vanillin-β-glucoside production over multiple generations, achieving higher yields in fermentation.

An orthogonal and pH-tunable sensor-selector for muconic acid biosynthesis in yeast

The paper develops a synthetic selection system in yeast to enrich for high-producing muconic acid variants by coupling production to cell fitness through a pH-tunable sensor-selector.