Author

Tan‐Yun Cheng

Brigham and Women's HospitalORCID 0000-0002-5178-6985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metagenomics· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

David Branch MoodyiD· 2 shared Jacob A. MayfieldiD· 2 shared Adam P. UldrichiD· 1 shared Adam ShahineiD· 1 shared Adriaan J. MinnaardiD· 1 shared Ana M. Xet-MulliD· 1 shared Annemieke de JongiD· 1 shared Aruna R. MenoniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

David Branch MoodyORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Sideways lipid presentation by the antigen-presenting molecule CD1c

Thinh-Phat Cao, Guan‐Ru Liao, Tan‐Yun Cheng, Yanqiong Chen, Laura Ciacchi, Thomas S. Fulford, Rachel Farquhar, Jade Kollmorgen, Jacob A. Mayfield, Adam P. Uldrich, Emily Zhi Qing Ng, Graham Stuart Ogg, Dale Ian Godfrey, Nicholas A. Gherardin, Y Chen, , Jamie Rossjohn

This study identifies a mechanism by which CD1c presents two lipids simultaneously, with bulky headgroups oriented sideways, enabling autoreactive TCR recognition.

Nature Communications · Dec 31, 2025Peer-reviewedImmunology

Mapping unsolved lipidomes accelerates lipid discovery in major bacterial pathogens

Yashodhan M. Nair, Aruna R. Menon, Zonghao Lin, Michiel R. L. Vossenberg, Vanisha Munsamy, David C. Young, Ana M. Xet-Mull, Gregory H. Babunovic, Tan‐Yun Cheng, Sahadevan Raman, Kyu Young Rhee, Jeremy M. Rock, Annemieke de Jong, Adriaan J. Minnaard, Jacob A. Mayfield, , D. Branch Moody

The paper maps unknown lipids in bacterial pathogens using lipidomic methods, revealing new biosynthetic products linked to virulence.

bioRxiv · Nov 6, 2025 · PreprintMicrobiology