Author

Hui‐Fern Koay

The University of MelbourneORCID 0000-0002-3236-9609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Calvin XuiD· 3 shared Dale Ian GodfreyiD· 3 shared David P. FairlieiD· 2 shared Jeffrey Y. W. MakiD· 2 shared Laura K. MackayiD· 2 shared Lynette BeattieiD· 2 shared Nicholas A. GherardiniD· 2 shared Adam P. UldrichiD· 1 shared

Activity by Year

2024-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

Calvin XuORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Specific targeting of MR1-antigen complexes using nanobodies

Hisham S. Hussain, Samuel J. Redmond, Wael Awad, Calvin Xu, Caroline Soliman, Huimeng Wang, Yuyang Zhang, Lisa Ciacchi, Alexis Perez‐Gonzalez, Jeffrey Y. W. Mak, David P. Fairlie, James McCluskey, Alexandra Jane Corbett, Adam P. Uldrich, Jamie Rossjohn, , Nicholas A. Gherardin

The paper develops a nanobody targeting MR1-5-OP-RU complexes and demonstrates its ability to modulate MAIT cell responses and act as a bispecific engager.

Science Immunology · Sep 25, 2026Peer-reviewedImmunology

γδ T cells modulate anti-tumor immunity in small cell lung cancer

Jin Ng, Yue You, Tina Z. Zhang, Jonas B. Hess, Sarah A. Best, Alex Caneborg, Marcel Schmiel, Sarah T. Diepstraten, Tim Spelman, Joshua I. Gray, Dale Ian Godfrey, Yin Wu, Richard W. Tothill, Casey J. A. Anttila, Tracey M. Baldwin, , Kate D. Sutherland

This study identifies γδ T cell infiltration in SCLC and shows their anti-tumor activity, suggesting they could be therapeutic targets.

Cancer Cell · Sep 18, 2026Peer-reviewedCancer Biology

Dynamic remodeling of chromatin during human mucosal-associated invariant T cell development

Marziyeh Taheri, Bowon Kim, Louis Perriman, Sedigheh Jalali, Christopher Menne, Igor E. Konstantinov, Adam T. Piers, Hui‐Fern Koay, Stuart P. Berzins, Boris Novakovic, Daniel Grant Pellicci

This study maps the chromatin dynamics during human MAIT cell development using CUT&Tag and transcriptome data, revealing H3K27ac changes linked to gene expression and effector program acquisition.

bioRxiv · Mar 20, 2026 · PreprintImmunology

Vγ1+ γδ T cell-derived IL-4 initiates CD8 T cell immunity

Shirley Le, Nick Dooley, Declan Murphy, Shangyi Liu, Luke C. Gandolfo, Zhengyu Ge, Rose May, Anton J. Cozijnsen, Thomas N. Burn, Charlie Jennison, Annabell Bachem, Calvin Xu, Hui‐Fern Koay, Jan Schröder, Damian A. Oyong, , Lynette Beattie

The paper shows Vγ1+ γδ T cells produce IL-4 to activate DC and CD8 T cells, enhancing immunity against Plasmodium.

Nature Immunology · Jan 30, 2026Peer-reviewedImmunology

Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signalling

Calvin Xu, Andreas Obers, Minyi Qin, Alice A. Brandli, Joelyn Wong, Xin Huang, Allison Clatch, Aly Fayed, Graham Starkey, Rohit D’Costa, Claire L. Gordon, Jeffrey Y. W. Mak, David P. Fairlie, Lynette Beattie, Laura K. Mackay, , Hui‐Fern Koay

This study shows that purinergic signaling via ARTC2 and P2RX7 regulates the survival and function of unconventional T cells, affecting IFN-γ and IL-4 production.

The Journal of Experimental Medicine · Oct 9, 2024Peer-reviewedImmunology