Depletion of all platelet integrins impacts hemostasis, thrombosis and tumor metastasis
Emily Janus‐Bell, Cristina Liboni, Alexandra A. Yakusheva, Vincent Mittelheisser, Clarisse Mouriaux, Catherine Bourdon, Louis Bochler, Vincent Hyenne, María Jesús García-León, Olivier Lefèbvre, Jacky G. Goetz, Pierre Mangin
This study shows that depleting all platelet integrins in mice increases bleeding time, impairs arterial thrombosis, and reduces tumor growth and metastasis.
iScience · Jul 31, 2025Peer-reviewedCancer Biology