Hao Sun

A Promoter Competition Hub Orchestrates Runx1 Alternative Promoter Usage during Skeletal Muscle Stem Cell Activation

caRBP-Pred: Deep Learning-based Prediction of Chromatin-Associated RNA-Binding Proteins Using Short Peptide Sequences

caRBP-Pred predicts chromatin-associated RNA-binding proteins using short peptide sequences, achieving an AUC of 0.81 and identifying 52 potential caRBPs in mice.

Spatial transcriptomic analysis of myositis muscles reveals novel molecular insights of MDA5+ dermatomyositis

This study uses spatial transcriptomics to analyze MDA5+ dermatomyositis muscles, revealing distinct transcriptomic profiles, immune cell infiltration, and vascular inflammation.

Imputation Disparities Driven by Recent Selectionand Their Impact on Disease Risk Estimation in East and Southeast Asian Populations

The paper evaluates imputation performance in East and Southeast Asian populations, showing that recent selection affects variant detection and polygenic risk score estimation.

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

PathoEye: a deep learning framework for the whole-slide image analysis of skin tissue

PathoEye is a deep learning framework for analyzing whole-slide skin images, focusing on the dermis-epidermis junction to identify features of skin diseases and aging.

Pervasive RNA Binding Protein Enrichment on TAD Boundaries Regulates TAD Organization

This study identifies RNA binding proteins (RBPs) as key regulators of TAD organization through their enrichment at TAD boundaries and synergistic interaction with nascent transcripts.

DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A/YTHDF1

This study shows DHX36 binding remodels RNA structure, particularly in 3UTRs, leading to decreased mRNA abundance via m6A and YTHDF1 interactions.

Nuclear m6A Reader YTHDC1 Promotes Muscle Stem Cell Activation/Proliferation by Regulating mRNA Splicing and Nuclear Export

This study identifies YTHDC1 as a critical regulator of muscle stem cell activation and proliferation by modulating mRNA splicing and nuclear export during regeneration.

seRNA PAM-1 regulates skeletal muscle satellite cell activation and aging through trans regulation of Timp2 expression synergistically with Ddx5

This study identifies PAM-1, a long non-coding RNA that regulates skeletal muscle satellite cell activation and aging by trans-regulating Timp2 expression with Ddx5.

In Vivo Study of Key Transcription Factors in Muscle Satellite Cells by CRISPR/Cas9/AAV9-sgRNA Mediated Genome Editing

This study develops a CRISPR/Cas9/AAV9-sgRNA system for in vivo genome editing in muscle satellite cells to investigate key transcription factors during activation and regeneration.