Hai Yu

Sialic Acid Identity Modulates Host Tropism of Sialoglycan-binding Viridans Group Streptococci

This study shows that sialic acid identity influences, but does not solely determine, host tropism of sialoglycan-binding streptococci by testing binding preferences of SLBRs to Neu5Ac and Neu5Gc.

The sialome of the retina, alteration in age-related macular degeneration (AMD) pathology and potential impacts on Complement Factor H

This study characterizes the sialome of the human retina and identifies alterations in age-related macular degeneration (AMD) that may impact complement factor H binding.

Simple and practical sialoglycan encoding system reveals vast diversity in nature and identifies a universal sialoglycan-recognizing probe derived from AB5 toxin B subunits

The paper introduces a 9-digit code system for sialyltrisaccharides, revealing vast sialoglycan diversity and identifying a universal probe from AB5 toxin B subunits.

Development and applications of sialoglycan-recognizing probes (SGRPs) with defined specificities: exploring the dynamic mammalian sialoglycome

The paper develops sialoglycan-recognizing probes (SGRPs) to systematically study mammalian sialoglycome dynamics using established laboratory techniques.

Biomolecular recognition of the glycan neoantigen CA19-9 by distinct antibodies

The paper studies how two antibodies recognize the glycan antigen CA19-9 using crystallography and computational methods to improve antibody affinity.

Rapid evolution of bacterial AB5 toxin B subunits independent of A subunits: sialic acid binding preferences correlate with host range and toxicity

The paper shows bacterial AB5 toxin B subunits evolve rapidly and independently of A subunits, with sialic acid binding preferences linked to host range and toxicity.