Haipeng Xue

This study shows that NEUROG2 can reprogram human microglial lineage cells into neurons both in vitro and in vivo, revealing a new pathway for neuronal replacement.

The paper demonstrates that hiPSC-derived A2B5+ NPCs can survive, differentiate into neurons and astrocytes, and improve functional recovery after spinal cord injury in mice.

This study shows that overexpressing MIF in hypoimmunogenic iPSC-derived NPCs reduces NK cell attack and improves engraftment in SCI models.

This paper introduces a trisomy 21-linked CSF2RB mutation in microglia that reduces neuroinflammation and enhances phagocytic functions, offering potential for AD therapy.

This study shows that OLIG2 overexpression in Down syndrome patient-derived iPSCs leads to abnormal neurodevelopmental phenotypes, including impaired recognition memory in chimeric mice.