Author

Gregory L. Wheeler

Nationwide Children's HospitalORCID 0000-0002-3291-6537Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Afrooz RashnonejadiD· 1 shared Allison M. BradburyiD· 1 shared Ben Kelly· 1 shared Burçak ÖzeşiD· 1 shared Cathal SeoigheiD· 1 shared Colin T. MaguireiD· 1 shared Devi Jaganathan· 1 shared Ebru Erzurumluoğlu GökalpiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenetics

Afrooz RashnonejadORCID

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2 papers

Recent·Most cited

A gene-centric analysis of copy number variation reveals tumour suppressor modulation of cancer risk and novel associations with common diseases

Sophie Matthews, Cathal Seoighe, Gregory L. Wheeler

This study uses a gene-centric analysis of copy number variation to identify associations between gene deletions and cancer risk, as well as novel links to common diseases.

bioRxiv · Oct 8, 2026 · PreprintGenomics

REMEDY: REpair of heterozygous Mutations independent of Exogenous Donor template with high efficiency using allele specific CRISPR targeting and HDR enhancers

Yasemin Sezgin, Genesis Snyder, Noushin Saljoughian, Colin T. Maguire, Ebru Erzurumluoğlu Gökalp, Devi Jaganathan, Eleonora Silvana D'Ambrosio, Burçak Özeş, Gregory L. Wheeler, Ben Kelly, Mark E. Hester, Zarife Sahenk, Sriram Vaidyanathan, Afrooz Rashnonejad, Jerry R. Mendell, , Meisam Naeimi Kararoudi

REMEDY enables efficient repair of heterozygous mutations in human and mouse cells without exogenous donor DNA by using CRISPR-induced DSBs and HDR enhancers.

bioRxiv · May 29, 2025 · PreprintGenetics