Author

Felix Sigmund

Helmholtz MunichORCID 0000-0002-3316-0882Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Assay:imaging· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Approach:contrastive learning· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Gil G. WestmeyeriD· 3 shared Steffen SchneideriD· 2 shared Afra M. Wohlschläger· 1 shared Alan JasanoffiD· 1 shared Albert J. R. HeckiD· 1 shared Albrecht StrohiD· 1 shared Anja Stelzl· 1 shared Arie GeerlofiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersSynthetic Biology

Gil G. WestmeyerORCID

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3 papers

Recent·Most cited

Cortex-Wide Preservation of Multi-Stimulus Information across Degrees of Network Synchronization

Silviu‐Vasile Bodea, Rodrigo González Laiz, Rhîannan H. Williams, Mariia Gladkova, Dominik Thalmeier, Bastian Rieck, Felix Sigmund, Marie Piraud, Afra M. Wohlschläger, Dominik Jüstel, Albrecht Stroh, Steffen Schneider, Gil G. Westmeyer

The paper decodes stimulus identity and network state from calcium imaging in mice across different anesthesia states, showing preserved stimulus information even during deep anesthesia.

bioRxiv · Dec 2, 2025 · PreprintNeuroscience

Iron-sequestering nanocompartments as multiplexed Electron Microscopy gene reporters

Felix Sigmund, Susanne Pettinger, Massimo Kube, Fabian Schneider, Martina Schifferer, Steffen Schneider, Maria V. Efremova, Jesús Pujol‐Martí, Michaela Aichler, Axel Karl Walch, Thomas Misgeld, Hendrik Dietz, Gil G. Westmeyer

The paper introduces a genetic iron-biomineralizing nanocompartment for multiplexed EM gene reporter imaging in mammalian cells.

ACS Nano · Jun 7, 2019Peer-reviewedSynthetic Biology

Eukaryotically expressed encapsulins as orthogonal compartments for multiscale molecular imaging

Felix Sigmund, Christoph Massner, Philipp S. Erdmann, Anja Stelzl, Hannes Rolbieski, Mitul Desai, Sarah Bricault, Tobias P. Wörner, Joost Snijder, Arie Geerlof, Helmut Fuchs, Martin Hrabě de Angelis, Albert J. R. Heck, Alan Jasanoff, Vasilis Ntziachristos, , Gil G. Westmeyer

The paper demonstrates the use of bacterial encapsulins in eukaryotic cells to create nanocompartments for localized enzymatic reactions and multiscale molecular imaging.

Nature Communications · May 14, 2018Peer-reviewedSynthetic Biology