Vasilis Ntziachristos

Vibrational optoacoustic detection of lipid-membrane dynamics enables label-free imaging of cell membrane potential

This paper introduces MIRACLES, a method to image cell membrane potential dynamics using vibrational optoacoustic detection, and demonstrates its application in monitoring glucose-stimulated insulin secretion in beta-cells.

Mutagenesis study of a Bacteriophytochrome - insights for the development of labels for optical imaging.

The paper studies a BphP from Rhizobium etli to identify variants suitable for optical imaging, including a bright far-red-shifted BphP and a photoswitching BphP for background suppression in vivo.

Single-cell metabolic imaging and digital scoring of fat tissue remodeling by label-free metabolic imaging

This study uses label-free metabolic imaging to analyze fat tissue remodeling at the single-cell level and introduces an AI tool for phenotypic assessment.

Protein-structure-sensitive mid-infrared optoacoustic microscopy enables label-free assessment of drug therapy in myeloma cells

This paper introduces a mid-infrared optoacoustic microscopy technique to label-free monitor drug therapy effects on myeloma cells by detecting intermolecular β-sheet formation.

Non-invasive optoacoustic imaging visualizes exercise-induced dermal revascularization in obese mice

The paper uses optoacoustic imaging to monitor microvascular changes in obese mice during exercise, showing improved vascular density and oxygenation in adipose tissues.

Eukaryotically expressed encapsulins as orthogonal compartments for multiscale molecular imaging

The paper demonstrates the use of bacterial encapsulins in eukaryotic cells to create nanocompartments for localized enzymatic reactions and multiscale molecular imaging.

Mid-infrared optoacoustic microscopy with label-free chemical contrast in living cells and tissues

This paper introduces MiROM, a mid-infrared optoacoustic microscopy technique that enables label-free chemical imaging in living cells and tissues with higher sensitivity than Raman imaging.