Hicham Drissi

Single-Cell Transcriptomics of Multi-Site Cell Therapy in Osteoarthritis: Tissue-Specific Traits and Treatment Correlations

This study uses single-cell RNA sequencing to analyze cell therapy samples in osteoarthritis, identifying tissue-specific pathways and treatment correlations while highlighting challenges in patient heterogeneity.

Multi-omics integration at cell type resolution uncovers gene-metabolite mechanisms underlying osteoarthritis heterogeneity

The paper integrates metabolomics and single-cell transcriptomics to uncover gene-metabolite mechanisms driving osteoarthritis heterogeneity.

Wnt5a gain- and loss-of-function present distinctly in craniofacial bone

This study examines the craniofacial and dental effects of Wnt5a gain- and loss-of-function in mice, finding distinct phenotypes that mirror the heterogeneity seen in Robinow syndrome.

Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

This study shows that PDGF-AB/BB treatment reduces senescence in human intervertebral disc cells by modulating gene expression related to cell cycle, metabolism, and oxidative stress.

Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects

This study investigates JAG1 delivery with pediatric human osteoblasts as a bone regenerative therapy for craniofacial defects in a murine model.

Chronic exposure to TNF reprograms cell signaling pathways in fibroblast-like synoviocytes by establishing long-term inflammatory memory

The paper identifies sustained gene expression and chromatin changes in fibroblast-like synoviocytes under chronic TNF exposure, revealing long-term inflammatory memory through persistent activation and repression of specific signaling pathways.

JAGGED1 Stimulates Cranial Neural Crest Cell Osteoblast Commitment Pathways and Bone Regeneration Independent of Canonical NOTCH Signaling

This study shows JAG1 promotes bone regeneration in mice by activating osteogenic pathways in cranial neural crest cells, independent of canonical NOTCH signaling.

A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells

This study identifies a non-canonical JAG1 signal to JAK2 pathway that mediates osteoblast commitment in cranial neural crest cells, independent of the canonical NOTCH pathway.