Brendan R. Tobin

This study identifies synaptic proteome changes in response to neuroinflammation, revealing mitochondrial and MAPK signaling disruptions in excitatory neurons linked to Alzheimer's disease.

The paper identifies novel Kv1.3 channel-interacting proteins in T-cells using proximity labeling, revealing interactions with immune signaling and trafficking machinery, and links some interactors to autoimmunity risk.

The paper identifies cross-species biomarkers and mechanisms in Rett Syndrome using gene therapy and multi-omic analysis in mice.

This study identifies YAP and TAZ as regulators of periosteal expansion during fracture repair, showing their role in cell proliferation and BMP4 regulation.

This study investigates JAG1 delivery with pediatric human osteoblasts as a bone regenerative therapy for craniofacial defects in a murine model.

The paper identifies plasma proteomic signatures associated with MLIV, showing decreased neuronal proteins and increased muscle proteins, with specific markers correlating with disease severity.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.