Jason D. Shepherd

This study shows that Arc-dependent capsid signaling between serotonergic and PAM neurons in Drosophila controls sleep depth by modulating arousal thresholds.

This study identifies Arc as critical for packaging tau into extracellular vesicles, facilitating its release and intercellular transmission in Alzheimer's disease.

The paper identifies persistent chromatin loops in hippocampal neurons after fear conditioning that correlate with gene expression changes during memory recall.

This study shows that dArc genes in Drosophila melanogaster regulate sugar reward valuation through capsid-mediated intercellular communication, affecting associative learning and reward valuation.

This study shows Arc EVs mediate intercellular synaptic plasticity through IRSp53-dependent biogenesis, leading to loss of surface AMPA receptors in neighboring dendrites.

The paper introduces a biohybrid transition microelectrode array for neural recording and modulation, aiming to improve biocompatibility and functionality through organic materials.

The paper identifies a second-guessing cognitive bias in foraging mice and shows that Arc deficiency reduces this bias, improving feeding outcomes.

This study shows PNMA2 forms virus-like capsids that trigger an autoimmune response, leading to paraneoplastic neurological syndrome.

This study investigates the role of the Arc gene in hippocampal long-term potentiation and finds that Arc is not required for LTP maintenance, suggesting alternative mechanisms for memory storage.

The paper identifies Arc as an activity-dependent gene involved in neurogenic inflammation through intercellular signaling via extracellular vesicles.

This study investigates how visual experience shapes binocular neuron development in the mouse visual cortex, finding that Arc-mediated plasticity is essential for normal circuit formation and maintenance.

The paper reports the structure of virus-like capsids formed by Drosophila Arc proteins and shows their similarity to retroviral and retrotransposon capsids.

This study shows that increasing Arc expression in adult mice restores juvenile-like plasticity in the visual cortex, suggesting Arc plays a key role in age-related declines in neural plasticity.