Sean A. Beausoleil

Expanding the Global Map of Protein Post Translational Modifications with Immunoaffinity Enrichment and nDIA Analysis on the Orbitrap Astral Mass Spectrometer

This study identifies numerous post-translational modification sites using immunoaffinity enrichment and nDIA mass spectrometry, showing nDIA's superior coverage and efficiency.

InTraSeq: A Multimodal Assay that Uncovers New Single-Cell Biology and Regulatory Mechanisms

InTraSeq is a multimodal scRNA-seq technology that simultaneously measures RNA and protein expression, revealing novel insights into Th17 cell differentiation and regulatory mechanisms.

Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway

The paper identifies a nucleus-to-mitochondria ROS sensing pathway involving CHK1 and SSBP1 that mediates resistance to platinum-based chemotherapies in ovarian cancers.