Author

Renfu Shang

ORCID 0000-0002-3361-3036Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Eric C. LaiiD· 3 shared Seungjae LeeiD· 2 shared Ankur GargiD· 1 shared Danwei HuangfuiD· 1 shared Dapeng YangiD· 1 shared David I.H. Jee· 1 shared Leemor Joshua‐ToriD· 1 shared Niko P. PopitschiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

Eric C. LaiORCID

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3 papers

Recent·Most cited

Human Dicer1 hotspot mutation induces both loss and gain of miRNA function

David I.H. Jee, Seungjae Lee, Dapeng Yang, Robert W. Rickert, Renfu Shang, Danwei Huangfu, Eric C. Lai

This study investigates the effects of a Dicer1 mutation on miRNA function, showing both loss and gain of miRNA activity through strand switching.

Nature Structural & Molecular Biology · Nov 4, 2025Peer-reviewedBiochemistry

Separable roles for Microprocessor and its cofactors ERH and SAFB1/2 during microRNA cluster assistance

Renfu Shang, Niko P. Popitsch, Seungjae Lee, Stefan Ludwig Ameres, Eric C. Lai

The paper investigates the roles of Microprocessor and its cofactors ERH and SAFB1/2 in miRNA cluster assistance, revealing their distinct functional contributions to the process.

bioRxiv · Sep 9, 2025 · PreprintMolecular Biology

The structural landscape of Microprocessor Mediated pri-let-7 miRNA processing

Ankur Garg, Renfu Shang, Todor Cvetanovic, Eric C. Lai, Leemor Joshua‐Tor

This study uses cryo-EM and biochemical analyses to reveal the structural flexibility of the Microprocessor in recognizing and processing different pri-let-7 miRNAs.

Molecular Cell · Oct 4, 2024Peer-reviewedBiochemistry