Author

Robert W. Rickert

Memorial Sloan Kettering Cancer CenterORCID 0000-0003-0285-7625Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Danwei HuangfuiD· 3 shared Christina S. LeslieiD· 2 shared Denis TorreiD· 2 shared Dingyu LiuiD· 2 shared Federico GonzãleziD· 2 shared Hyunwoo ChoiD· 2 shared Jeyaram Ravichandran DamodaraniD· 2 shared Julián PulecioiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Danwei HuangfuORCID

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3 papers

Recent·Most cited

Developmental BiologyCell GenomicsPeer-reviewedMar 18, 2026

Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells

Julián Pulecio, Zakieh Tayyebi, Dingyu Liu…·Danwei Huangfu

The paper identifies pre-established chromatin regions in human ESCs that enable rapid activation of lineage-specific genes during differentiation.

5 citations

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Cancer BiologybioRxivPreprintMar 11, 2026

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation

X Zhang, W. Douglas Wong, Hyunwoo Cho…·Danwei Huangfu

This paper develops a human organoid model of early PDAC that identifies genetic and epigenetic barriers to lineage plasticity, showing CDKN2A loss is essential with KRAS/TP53 mutations and TET1 suppression links ERK signaling to transcription factor silencing.

DOI 10.64898/2026.03.09.710586

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BiochemistryNature Structural & Molecular BiologyPeer-reviewedNov 4, 2025

Human Dicer1 hotspot mutation induces both loss and gain of miRNA function

David I.H. Jee, Seungjae Lee, Dapeng Yang…·Eric C. Lai

This study investigates the effects of a Dicer1 mutation on miRNA function, showing both loss and gain of miRNA activity through strand switching.

5 citations

humanbulk RNA-seq

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