Author

Szymon Juszkiewicz

GenentechORCID 0000-0002-3361-7264Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alejandro Martinez ChiblyiD· 1 shared Anwesha DeyiD· 1 shared Dexter X. JiniD· 1 shared Ethan S. SokoliD· 1 shared Eun‐Jung KimiD· 1 shared Jack KammiD· 1 shared Kevin CabreraiD· 1 shared Kristel M. DorighiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alejandro Martinez ChiblyORCID

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2 papers

Recent·Most cited

Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells

Eun‐Jung Kim, Dexter X. Jin, Alejandro Martinez Chibly, Kristel M. Dorighi, Smruthy Sivakumar, Jack Kamm, Szymon Juszkiewicz, Kevin Cabrera, Rohit Reja, Yangmeng Wang, Rachel M. Nakagawa, Minyi Shi, Yuxin Liang, Anwesha Dey, Ethan S. Sokol, , Meng He

The paper identifies synthetic lethality between POLE exonuclease deficiency and high aneuploidy in cancer cells, suggesting POLE inhibition as a therapeutic strategy for aneuploid tumors.

Cancer Research · Jun 8, 2026Peer-reviewedCancer Biology

Mechanism of chaperone recruitment and retention on mitochondrial precursors

Szymon Juszkiewicz, Sew‐Yeu Peak‐Chew, Ramanujan S. Hegde

The paper shows that the mitochondrial targeting signal (MTS) regulates chaperone dynamics on mitochondrial precursors to buffer degradation and maintain import competence during stress.

Molecular Biology of the Cell · Jan 29, 2025Peer-reviewedCell Biology