Sergi Castellano

This study identifies three leukaemia stem cell subtypes in paediatric AML and shows that combining CLEC12A and CD84 targets all subtypes while sparing healthy cells.

The paper evaluates single cell transcriptomic methods on challenging placental tissue, finding that sample processing and storage have greater impact on results than technical variations.

This study compares in vivo and in vitro midbrain development to assess their similarity to human fetal tissue.

This study identifies spatially distinct fetal and maternal cell contributions to severe preeclampsia, highlighting new maternal immune signatures and potential therapeutic targets.

This study compares metagenomics and targeted approaches for virus detection, finding that targeted methods improve sensitivity while untargeted ONT offers better specificity.

The paper reconstructs and assays ancient enzymes to show that losing selenocysteine in GPX6 led to functional loss and convergent evolution in mammalian oxidoreductases.

Dawnn improves identification of differentially abundant cell populations in single-cell data, outperforming existing methods for both common and rare cell types.

This study investigates how somatic mutations affect dopaminergic neuron differentiation in iPSCs, finding that deleterious mutations in key genes like BCOR are linked to differentiation failure and altered proliferation.