Author

David Valle‐García

Boston Children's HospitalORCID 0000-0002-3397-3103Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Abhinav DhalliD· 1 shared Abraham Román-FigueroaiD· 1 shared Augusto César Poot-HernándeziD· 1 shared Carlos Alberto Peralta‐ÁlvareziD· 1 shared Erdem SendinciD· 1 shared Félix Recillas TargaiD· 1 shared Francisco Pinta-Castro· 1 shared Hao Chen· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Abhinav DhallORCID

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2 papers

Recent·Most cited

Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of de novo Polycomb recruitment

Itzel Alejandra Hernández-Romero, Carlos Alberto Peralta‐Álvarez, Abraham Román-Figueroa, Rosario Pérez‐Molina, Nallely Cano-Domínguez, Maribel Soto-Nava, Francisco Pinta-Castro, Sylvia Garza-Manero, Hongwei Zhou, Xin Huang, Félix Recillas Targa, Augusto César Poot-Hernández, Mayra Furlan-Magaril, Santiago Ávila‐Ríos, David Valle‐García, , Víctor Julián Valdés

The paper identifies PRC2 nucleation sites in mESCs after Suz12 reintroduction, revealing chromatin states, DNA sequences, cofactors, and spatial interactions involved in de novo Polycomb recruitment.

Epigenetics & Chromatin · Sep 18, 2026Peer-reviewedMolecular Biology

PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression

Erdem Sendinc, David Valle‐García, Abhinav Dhall, Hao Chen, Telmo Henriques, José Navarrete-Perea, Wanqiang Sheng, Steven P. Gygi, Karen Adelman, Yang Shi

The paper identifies PCIF1 as the first human m6Am methyltransferase and shows it regulates gene expression by suppressing cap-dependent translation through m6Am methylation.

Molecular Cell · Jul 3, 2019Peer-reviewedMolecular Biology