Félix Recillas Targa

Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of de novo Polycomb recruitment

The paper identifies PRC2 nucleation sites in mESCs after Suz12 reintroduction, revealing chromatin states, DNA sequences, cofactors, and spatial interactions involved in de novo Polycomb recruitment.

TIF1γ regulates stability of T regulatory cells during inflammation

This study shows that TIF1γ maintains T regulatory cell stability and suppressor function during inflammation by regulating Foxp3 expression and the beta-catenin pathway.

In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila

This study shows that deleting domain boundaries in Drosophila causes TAD fusion and transcription defects, highlighting their role in genome organization and gene regulation.

Genome-wide 5-hydroxymethylcytosine (5hmC) emerges at early stage of in vitro hepatocyte differentiation

The paper shows that 5-hydroxymethylcytosine (5hmC) increases genome-wide during early hepatocyte differentiation and its modulation affects hepatic identity markers.