Author

Michael M. Müller

University of East AngliaORCID 0000-0002-5930-9905Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1

Frequent Co-Authors

David VauzouriD· 3 shared Egle SolitoiD· 2 shared Gwénaëlle Le GalliD· 2 shared Lesley HoylesiD· 2 shared Matthew G. PontifexiD· 2 shared Robert Charles GleniD· 2 shared Simon McArthuriD· 2 shared Ana L. CarvalhoiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersSystems Biology

David VauzourORCID

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3 papers

Recent·Most cited

Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate isprevented by blockade of the epidermal growth factor receptor

Sita Shah, Tobias B-A. Knausenberger, Matthew G. Pontifex, Emily Connell, Gwénaëlle Le Gall, Tom A. J. Hardy, David W. Randall, Kieran McCafferty, Muhammad Magdi Yaqoob, Egle Solito, Michael M. Müller, Andrew V. Stachulski, Robert Charles Glen, David Vauzour, Lesley Hoyles, Simon McArthur

This study shows p-cresol sulfate impairs the blood-brain barrier via EGFR activation and demonstrates EGFR blockade prevents this damage in vitro.

Gut Microbes · Nov 24, 2024Peer-reviewedSystems Biology

Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodríguez‐Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sónia Fonseca, Ana L. Carvalho, Simon Richard Carding, Michael M. Müller, Robert Charles Glen, David Vauzour, Simon McArthur

This study shows that TMAO enhances BBB integrity and protects against inflammation, while TMA impairs BBB function and cognitive resilience in mice.

Microbiome · Nov 26, 2021Peer-reviewedSystems Biology

Association between Apolipoprotein E genotype and the gut microbiome composition in humans and mice

Tam T. T. Tran, Simone Corsini, Lee Kellingray, Claire Hegarty, Gwénaëlle Le Gall, Arjan Narbad, Michael M. Müller, Noemı́ Tejera, Paul William O’Toole, Anne Marie Minihane, David Vauzour

This study investigates the association between APOE genotype and gut microbiome composition in humans and APOE-TR mice, finding specific microbial and metabolic differences linked to APOE alleles.

The FASEB Journal · Apr 8, 2019Peer-reviewedGenomics