Rachel E. Lacoursiere

HOIL1 mediates MDA5 activation through ubiquitination of LGP2

This study shows HOIL1 ubiquitinates LGP2 to activate MDA5 and induce IFN responses, highlighting a mechanism distinct from RIG-I sensing.

Ubiquitin isopeptidase and esterase activities have distinct catalytic requirements

This study shows that isopeptidase and esterase activities of deubiquitinases have distinct catalytic requirements, with cysteine not strictly needed for esterase activity.

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

The paper identifies RNF114 as an E3 ligase that extends K11 polyubiquitin on MARUbylated sites, revealing a novel mechanism of Ub-ADPr recognition and polyubiquitylation.

Discovery of ester-linked ubiquitylation of PARP10 mono-ADP-ribosylation in cells: a dual post-translational modification on Glu/Asp side chains

This paper discovers a new dual post-translational modification, MARUbylation, where PARP10 is mono-ADP-ribosylated and ubiquitylated on Glu/Asp residues, leading to proteasomal degradation.