The Type VI Secretion System Antifungal Effector Tfe2 Inhibits Protein Translation and Drives Hyperactivation of TORC1.
Katharina Trunk, Genady Pankov, Alex Anderton, Viktoras Stonys, Andrew Michael Frey, Jennifer H. Haggarty, Ian Leaves, Pantelitsa Papakyriacou, Mengchun Li, Vivek Manthri, Flávia M. Zimbres, Paul William Denny, Phillip D. Whitfield, Christian Hacker, Neil A. R. Gow, , Janet Quinn
This study identifies Tfe2 as a novel antifungal effector that inhibits protein translation and hyperactivates TORC1, leading to cellular remodeling in yeast.
bioRxiv · Nov 20, 2025 · PreprintMicrobiology