Phillip D. Whitfield

Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction

This study shows adiponectin influences sex-specific metabolic changes during caloric restriction, affecting glucose, lipid, and amino acid metabolism through hepatic mechanisms.

Comparative lipidomic profiling of the livestock pathogens Trypanosoma congolense and Trypanosoma brucei

This study compares lipidomic profiles of Trypanosoma congolense and Trypanosoma brucei to understand their metabolic differences and implications for in vitro culture and therapy development.

Spermidine enhances metabolic flexibility and attenuates inflammation associated with ageing in farmed Atlantic salmon

This study identifies a metabolic-ageing profile in Atlantic salmon similar to humans and shows that spermidine supplementation reduces inflammation and improves metabolic flexibility in aged fish.

The Type VI Secretion System Antifungal Effector Tfe2 Inhibits Protein Translation and Drives Hyperactivation of TORC1.

This study identifies Tfe2 as a novel antifungal effector that inhibits protein translation and hyperactivates TORC1, leading to cellular remodeling in yeast.

Inhibition of systemic mammalian metabolism by carnitine mimics from the gut microbiota

This study investigates the systemic effects of microbiome-derived carnitine analogues in mice, showing carnitine depletion and mitochondrial dysfunction due to inhibition of carnitine biosynthesis.

Rapamycin induced autophagy enhances lipid breakdown and ameliorates lipotoxicity in Atlantic salmon cells.

This study shows that rapamycin-induced autophagy enhances lipid breakdown and reduces lipotoxicity in Atlantic salmon cells.

Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice

This study shows that knocking down Hsd17b13 in obese mice reduces liver steatosis and improves liver health markers, suggesting HSD17B13 as a therapeutic target for MASLD.

Characterization of the role of glycine lipids in Bacteroides thetaiotaomicron

This study identifies the genetic requirements for biosynthesis of diacylated glycine lipids in Bacteroides thetaiotaomicron and shows their role in stress adaptation and gut colonization.