Author

Neil A. R. Gow

University of ExeterORCID 0000-0002-2776-5850Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:C. elegans· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ian LeavesiD· 3 shared Alex Anderton· 1 shared Alice DesgardiniD· 1 shared Alistair J. P. BrowniD· 1 shared Andrew Michael FreyiD· 1 shared Angela H. NobbsiD· 1 shared Arnab PradhaniD· 1 shared Ben A Caswall· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Ian LeavesORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

C. albicans ergosterol modulates the antifungal response of human neutrophils by masking β-glucan

Huan Jiang, Angela H. Nobbs, Ian Leaves, Neil A. R. Gow, Stephanie Diezmann, Borko Amulic

This study shows that reducing ergosterol in C. albicans increases neutrophil ROS production and phagocytosis, while decreasing NET formation, suggesting ergosterol masks β-glucan to evade immune detection.

bioRxiv · May 18, 2026 · PreprintMicrobiology

FKS1/2-variant independent mechanisms underlying the emergence of resistance in echinocandin-refractory Candida auris infections

Hugh Gifford, Arnab Pradhan, Ben A Caswall, Sarah Murphy, Ian Leaves, Matt B. Edmondson, Tanmoy Chakraborty, Duncan Wilson, Surabhi K. Taori, Neil A. R. Gow, Rhys A. Farrer, Alistair J. P. Brown, Tihana A. Bicanic

This study identifies FKS1/2-variant independent mechanisms of echinocandin resistance in Candida auris through genomic and phenotypic analysis of clinical isolates.

bioRxiv · Jan 18, 2026 · PreprintMicrobiology

The Type VI Secretion System Antifungal Effector Tfe2 Inhibits Protein Translation and Drives Hyperactivation of TORC1.

Katharina Trunk, Genady Pankov, Alex Anderton, Viktoras Stonys, Andrew Michael Frey, Jennifer H. Haggarty, Ian Leaves, Pantelitsa Papakyriacou, Mengchun Li, Vivek Manthri, Flávia M. Zimbres, Paul William Denny, Phillip D. Whitfield, Christian Hacker, Neil A. R. Gow, , Janet Quinn

This study identifies Tfe2 as a novel antifungal effector that inhibits protein translation and hyperactivates TORC1, leading to cellular remodeling in yeast.

bioRxiv · Nov 20, 2025 · PreprintMicrobiology

Unveiling Cell Wall Structure and Echinocandin Response in Candida auris and Candida albicans via Solid-State NMR

Malitha C. Dickwella Widanage, Kalpana Singh, Jizhou Li, Jayasubba Reddy Yarava, Faith J. Scott, Yifan Xu, Neil A. R. Gow, Frédéric Mentink‐Vigier, Ping Wang, Frédéric Lamoth, Tuo Wang

This study uses solid-state NMR to analyze how echinocandin treatment alters cell wall structures in Candida auris and Candida albicans, revealing structural changes linked to drug resistance.

Nature Communications · Jul 8, 2025Peer-reviewedMicrobiology

Card9 and MyD88 differentially regulate Th17 immunity to the commensal yeast Malassezia in the murine skin

Meret Tuor, Mark H. T. Stappers, Alice Desgardin, Fiorella Ruchti, Florian Sparber, Selinda J. Orr, Neil A. R. Gow, Salomé LeibundGut‐Landmann

The paper investigates how Card9 and MyD88 regulate Th17 immunity against Malassezia in murine skin, showing Dectin-2's role in Th17 activation and MyD88's involvement in T cell-intrinsic signaling.

Mucosal Immunology · Nov 22, 2024Peer-reviewedImmunology

Beta-1,6-glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall

Clara Bekirian, Isabel Valsecchi, Sophie Bachellier‐Bassi, Cyril Scandola, J. Iñaki Guijarro, Murielle Chauvel, Thierry Mourer, Neil A. R. Gow, Vishukumar Aimanianda, Christophe d’Enfert, Thierry Fontaine

This study identifies beta-1,6-glucan as essential for fungal cell wall structure, integrity, and host-pathogen interactions.

eLife · Sep 2, 2024Peer-reviewedMicrobiology