Author

Guillaume Bernas

Centre Hospitalier de l’Université de MontréalORCID 0000-0002-3495-5732Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Catherine LarochelleiD· 2 shared Mariette Ouellet· 2 shared Aidan R. O’BrieniD· 1 shared Amy Gonzales· 1 shared Andréa Barrios· 1 shared Andrew S. I. LoudoniD· 1 shared Andrew W. TraffordiD· 1 shared Ane Miren SalvadoriD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Catherine LarochelleORCID

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3 papers

Recent·Most cited

PhysiologyThe FASEB JournalPeer-reviewedJun 14, 2025

Brain-specific Gata4 downregulation in Greywick female mice models the metabolic subtype of polycystic ovary syndrome

Sherin Ali Nawaito, Mostafa Esmael, Ouliana Souchkova…·Nicolas Pilon

This study shows that Gata4 downregulation in the hypothalamus of Greywick female mice models the metabolic subtype of PCOS by affecting fertility and food intake genes.

5 citations

mousebulk RNA-seq

Molecular BiologyBMC BiotechnologyPeer-reviewedMay 12, 2022

Introduction of loxP sites by electroporation in the mouse genome; a simple approach for conditional allele generation in complex targeting loci.

Guillaume Bernas, Mariette Ouellet, Andréa Barrios…·Jean-François Schmouth

The paper describes a modified electroporation method to generate conditional allele mouse models using two strategies, achieving targeting efficiencies between 3-25% for eight genes.

6 citations

mouseexperimental assay

GeneticsGenome biologyPeer-reviewedAug 25, 2019

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros…·Atsushi Yoshiki

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.

102 citationstop 3%

mousestatistical model